DETAILS, FICTION AND INTERLEUKIN-2 MECHANISM OF ACTION

It's very well understood that IL-2 is a pleiotropic cytokine positioned for the crossroads of T mobile activation and regulation. As such, it is essential to engineer an IL-2 molecule which is biased in direction of effector cells bearing the intermediate affinity receptor, like naïve and memory CD8+ T cells and NK cells, as opposed to Treg cells